Expression profiles of long non-coding RNAs (lncRNAs) across diverse biological conditions provide significant insights into their biological functions, interacting targets as well as transcriptional reliability. However, there lacks a comprehensive resource that systematically characterizes the expression landscape of human lncRNAs ...
Read More »Detection of RNA-DNA binding sites in long noncoding RNAs
Long non-coding RNAs (lncRNAs) can act as scaffolds that promote the interaction of proteins, RNA, and DNA. There is increasing evidence of sequence-specific interactions of lncRNAs with DNA via...
Read More »A new resource may help RNA researchers go long in ALS
The ALS Research Forum – A new genomic resource may help researchers unravel the role of key RNA-binding proteins in ALS. The atlas, developed at the Riken Institute in Yokohama, Japan, contains 27,919 long non-coding RNAs – including 19,175 potentially ...
Read More »Splicing-based RNA tagging (SRT) – a new method for tissue-specific RNA-seq of transgenic worms
Current approaches to profiling tissue-specific gene expression in C. elegans require delicate manipulation and are difficult under certain conditions, e.g. from dauer or aging worms. Researchers at Tsinghua University have developed an easy and robust method for tissue-specific RNA-seq by ...
Read More »RACE-Seq – extension of human lncRNA transcripts by RACE coupled with long-read high-throughput sequencing
Long non-coding RNAs (lncRNAs) constitute a large, yet mostly uncharacterized fraction of the mammalian transcriptome. Such characterization requires a comprehensive, high-quality annotation of their gene structure and boundaries, which is currently lacking. Here researchers from the Barcelona Institute of Science ...
Read More »Biogazelle and Isis evaluate long non-coding RNAs to identify and validate novel targets for anti-cancer drugs
GHENT, Belgium, October 15, 2015 – Biogazelle NV today announced a research-stage collaboration with Isis Pharmaceuticals in which they will identify and validate novel targets to treat colon, liver and lung cancer, diseases with clear unmet clinical needs. As part ...
Read More »zflncRNApedia – A Comprehensive Online Resource for Zebrafish Long Non-Coding RNAs
Recent transcriptome annotation using deep sequencing approaches have annotated a large number of long non-coding RNAs in zebrafish, a popular model organism for human diseases. These studies characterized lncRNAs in critical developmental stages as well as adult tissues. Each of ...
Read More »Annocript – a flexible pipeline for the annotation of transcriptomes also able to identify putative long noncoding RNAs
The eukaryotic transcriptome is composed of thousands of coding and long noncoding RNAs (lncRNAs). However, we lack a software platform to identify both RNA classes in a given transcriptome. Here researchers from the Anton Dohrn – Zoological Station introduce Annocript, ...
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