Tag Archives: m6A

N6-methyladenosine (m6A) is an abundant RNA modification that plays critical roles in RNA regulation and cellular function. Global m6A...

Epigenetic modifications control the stability and translation of mRNA molecules. Researchers from Massachusetts General Hospital and Harvard Medical School have developed a microscopy-based platform for quantifying modified RNA molecules and for relating the modification patterns to single-cell phenotypes. The researchers ...

RNA modifications, such as N6-methyladenosine (m6A), modulate functions of cellular RNA species. However, quantifying differences in RNA...

When cancers metastasize, cells from the primary tumor break away, travel through the blood or lymph system, and form new tumors in other body parts. Although metastasis are responsible for more than 90% of all cancer deaths, limited progress has ...

The fates of RNA species in a cell are controlled by ribonucleases, which degrade them by exploiting the universal structural 2′-OH group. This phenomenon plays a key role in numerous transformative...

An epitranscriptome is a set of functionally appropriate RNA modifications. There are nearly one hundred known modifications of RNA; the most common modification in internal mRNA is...

In 2004, oncologist Gideon Rechavi at Tel Aviv University in Israel and his colleagues compared all the human genomic DNA sequences then available with their corresponding messenger RNAs — the molecules that carry the information needed to make a protein ...