Tag Archives: mass spectrometry

Combining RNA-Seq Proteogenomics and Global Post-Translational Modification (G-PTM) Search Strategy Reveals Human Proteomic Variation

Mass spectrometry-based proteomic analysis underestimates proteomic variation due to the absence of variant peptides and posttranslational modifications (PTMs) from standard protein databases. Each individual carries thousands of missense mutations that lead to single amino acid variants, but these are missed ...

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Using galaxy-P to leverage RNA-Seq for the discovery of novel protein variations

rna-seq

Current practice in mass spectrometry (MS)-based proteomics is to identify peptides by comparison of experimental mass spectra with theoretical mass spectra derived from a reference protein database; however, this strategy necessarily fails to detect peptide and protein sequences that are ...

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