Tag Archives: Max Planck Institute for Molecular Genetics

New technology enables single cell analysis of mouse embryonic development Scientists from Seattle and Berlin have published an atlas on mouse embryonic...

RNA sequencing is a powerful method to build reference transcriptome assemblies and eventually sample-specific protein databases for mass spectrometry-based analyses. This novel proteomics informed by transcriptomics (PIT) workflow improves sample-specific proteome characterization of dynamic- and especially non-model organism proteomes, and ...

Mass spectrometry-based methods allow for the direct, comprehensive analysis of expressed proteins and their quantification among different conditions. However, in general identification of proteins by assigning experimental mass spectra to peptide sequences of proteins relies on matching mass spectra to ...

Detailed molecular analyses allow new insights into the function of tumour cells and new treatments Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. It can occur in various forms, differing by specific changes in the ...

Gene expression analysis by RNA sequencing is now widely used in a number of applications surveying the whole transcriptomes of cells and tissues. The recent introduction of ribosomal RNA depletion protocols, such as RiboZero, has extended the view of the ...

The computational prediction of alternative splicing from high-throughput sequencing data is inherently difficult and necessitates robust statistical measures because the differential splicing signal is overlaid by influencing factors such as gene expression differences and simultaneous expression of multiple isoforms amongst ...