Tag Archives: Memorial Sloan-Kettering Cancer Center

Targeted next-generation sequencing of DNA has become more widely used in the management of patients with lung adenocarcinoma; however, no clear mitogenic driver alteration is found in some cases. Researchers at Memorial Sloan Kettering Cancer...

Single-cell RNA sequencing studies of differentiating systems have raised fundamental questions regarding the discrete versus continuous nature of both differentiation and cell fate. Researchers from Memorial Sloan Kettering Cancer Center present Palantir, an algorithm that models trajectories of differentiating cells ...

DNA mutations are known cancer drivers. Memorial Sloan Kettering Cancer Center researchers investigated whether mRNA events that are upregulated in cancer can functionally mimic the outcome of...

Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region (3’UTR) length but can also recognize intronic polyadenylation (IpA) signals to generate transcripts that lose part or all of the coding region. Researchers from Memorial Sloan Kettering Cancer Center ...

Alternative polyadenylation (APA) diversifies the 3′ termini of a majority of mRNAs in most eukaryotes, and is consequently inferred to have substantial consequences for the utilization of post-transcriptional regulatory mechanisms. Since conventional RNA-sequencing methods do not accurately define mRNA termini, ...

Driven by the recent advances of next generation sequencing (NGS) technologies and an urgent need to decode complex human diseases, a multitude of large-scale studies were conducted recently that have resulted in an unprecedented volume of whole transcriptome sequencing (RNA-seq) ...

CAMBRIDGE, Mass. & NEW YORK–(BUSINESS WIRE)–Foundation Medicine, Inc. (NASDAQ:FMI) and Memorial Sloan Kettering Cancer Center (MSK) today announced the publication of new, seminal data validating FoundationOne® Heme – the fully informative comprehensive genomic profiling assay for hematologic malignancies developed as ...

Understanding the occurrence and regulation of alternative splicing (AS) is a key task towards explaining the regulatory processes that help to shape the complex transcriptomes of higher eukaryotes. With the advent of high-throughput sequencing of RNA, the diversity of AS ...

A team led by researchers at the Memorial Sloan-Kettering Cancer Center present Oqtans, an open-source workbench for quantitative transcriptome analysis, that is integrated in the Galaxy framework. Its distinguishing features include customizable computational workflows and a modular pipeline architecture that ...