Tag Archives: microrna

While the amount of small non-coding RNA sequencing data is continuously increasing, it is still unclear to which extent small RNAs are...

Since the small RNA-sequencing (sRNA-seq) technology became available, it allowed the discovery of thousands new microRNAs (miRNAs) in humans and many other species, providing new data on these small RNAs (sRNAs) of high biological and translational relevance. MiRNA discovery has ...

miRNAs are small non-coding RNAs (ncRNAs) (21–23 nt long) that regulate gene expression at the post-transcriptional level by binding to messenger RNAs (mRNAs) and inhibiting their translation into proteins or by binding to other ncRNAs. First discovered in 1993 in Caenorhabditis ...

MicroRNAs (miRNAs) are small (19-25 base long), non-coding RNAs that regulate post-transcriptional gene expression by cleaving targeted mRNAs in several eukaryotes. The miRNAs play vital roles in multiple biological and metabolic processes, including developmental timing, signal transduction, cell maintenance and ...

The analysis of small RNA NGS data together with the discovery of new small RNAs is among the foremost challenges in life science. For the analysis of raw high-throughput sequencing data Saarland University researchers implemented the fast, accurate and comprehensive ...

Next generation sequencing is a key technique in small RNA biology research that has led to the discovery of functionally different classes of small non-coding RNAs in the past years. However, reliable annotation of the extensive amounts of small non-coding ...

MicroRNAs carry out post-transcriptional gene regulation in animals by binding to the 3′ untranslated regions of mRNAs, causing their degradation or translational repression. MicroRNAs influence many biological functions, and dysregulation can therefore disrupt development or even cause death. High-throughput sequencing ...

Single molecule microRNA technology proves useful for liver toxicity detection Breakthrough research published in PLOS ONE demonstrates quantitative, PCR-free detection of microRNA https://www.eurekalert.org/pub_releases/2017-07/q-smm062917.php Quanterix Corporation, a company digitizing biomarker analysis with the goal of advancing the science of precision health, ...

Prostate cancer is the most common non-cutaneous cancer among men; yet, current diagnostic methods are insufficient, and more reliable diagnostic markers need to be developed. One answer that can bridge this gap may lie in microRNAs. These small RNA molecules ...

MicroRNAs (miRNAs) released into the peripheral circulation upon cellular injury have shown a promise as a new class of tissue-specific biomarkers. Researchers from Maastricht University were first to demonstrate that next-generation sequencing analysis of serum from human subjects with acetaminophen-induced ...