Tag Archives: microrna

MicroRNAs (miRNA) are small endogenous RNA molecules, which regulate target gene expression at post-transcriptional level. Besides, miRNA activity can be controlled by a newly discovered regulatory mechanism called endogenous target mimicry (eTM). In target mimicry, eTMs bind to the corresponding ...

The ability to profile mRNAs in single cells has transformed the molecular identification and the characterization of cell types, states and rare cellular phenotypes. However, current single-cell methods are restricted to long RNAs, primarily mRNAs. Several classes of small RNAs ...

Added on: 15/09/2016 – Expires on: 15/10/2016 We are seeking a postdoctoral candidate to join the “microRNAs and non-coding RNAs in development and disease” team led by Dr. Francesco Nicassio. The Center for Genomic Science of IIT@SEMM (https://www.iit.it/it/centri/cgs-semm), located in ...

microRNAs (miRNAs) are small non-coding RNAs that regulate cellular processes through modulation of proteins at the translational level. They tend to be highly stable as compared to other RNA species due to their small size and protection by protein and/or ...

Changes in small non-coding RNAs such as micro RNAs (miRNAs) can serve as indicators of disease and can be measured using next-generation sequencing of RNA (RNA-seq). Here, University of Maryland rsearchers highlight the need for approaches that complement RNA-seq, discover ...

Functional interpretation of miRNA expression data is currently done in a three step procedure: select differentially expressed miRNAs, find their target genes, and carry out gene set overrepresentation analysis Nevertheless, major limitations of this approach have already been described at ...

Performing qPCR-based profiling of microRNA from single cells or small cell numbers? Our July 12 webinar will definitely help you get the most out of your precious samples! The webinar focuses on a new, streamlined process for differential expression profiling based on ...

from – The Huffington Post by Landess Kearns –  A new study found a key genetic element shared by animals with regenerative abilities. Limb regeneration may seem like a science-fiction super power reserved for lizards and starfish, but a new ...

Circulating biomarkers are urgently needed in HCC. miRNA are noncoding RNA that regulate mRNA expression and are detectable in tumor tissue and extracellular compartments. This pilot study explored the feasibility of using next-generation RNA sequencing to characterize miRNA abundance in ...

Genomic alignment of small RNA (smRNA) sequences such as microRNAs poses considerable challenges due to their short length (∼21 nucleotides [nt]) as well as the large size and complexity of plant and animal genomes. While several tools have been developed ...