MicroRNAs (miRs) are short non-coding RNAs that fine-tune the regulation of gene expression to coordinate a wide range of biological processes. Because of their role in the regulation of gene expression, miRs are essential players in development by acting on ...
Read More »Next-generation sequencing data considered alone are limited for assessing the absolute copy number of microRNA transcripts
Researchers from Université de Tours, France analyzed the effect of small RNA library preparation and sequencing on the miRNA frequencies obtained from the same RNA samples collected during MDV-1 infection of chicken at different steps of the oncoviral pathogenesis. Qualitative and ...
Read More »TargetRNA2 – identifying targets of small regulatory RNAs in bacteria
Many small, noncoding RNAs (sRNAs) in bacteria act as posttranscriptional regulators of messenger RNAs. TargetRNA2 is a web server that identifies mRNA targets of sRNA regulatory action in bacteria. As input, TargetRNA2 takes the sequence of an sRNA and the ...
Read More »eRNA: a graphic user interface-based tool optimized for large data analysis from high-throughput RNA sequencing
RNA sequencing (RNA-seq) is emerging as a critical approach in biological research. However, its high-throughput advantage is significantly limited by the capacity of bioinformatics tools. The research community urgently needs user-friendly tools to efficiently analyze the complicated data generated by ...
Read More »The MicroRNA Expression Signature of Bladder Cancer by Deep Sequencing
Current genome-wide microRNA (miRNA) expression signature analysis using deep sequencing technologies can drive the discovery of novel cancer pathways regulated by oncogenic and/or tumor suppressive miRNAs. Researchers at Kagoshima University, Japan determined the genome-wide miRNA expression signature in bladder cancer ...
Read More »Visualization of MicroRNA Sequence Data Analysis
Visualization of MicroRNA Sequence Data Analysis Mayuko C. Inoue
Read More »Identification of miRNAs and their target genes in developing maize ears by combined small RNA and degradome sequencing
In plants, microRNAs (miRNAs) are endogenous ~22 nt RNAs that play important regulatory roles in many aspects of plant biology, including metabolism, hormone response, epigenetic control of transposable elements, and stress response. Extensive studies of miRNAs have been performed in ...
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