Haplotype reconstruction of distant genetic variants remains an unsolved problem due to the short-read length of common sequencing data. Here, MIT researchers introduce HapTree-X, a probabilistic...
Read More »Researchers use single cell RNA sequencing to identify cells likely targeted by Covid-19 virus
Study finds specific cells in the lungs, nasal passages, and intestines that are more susceptible to infection. Researchers at MIT; the Ragon...
Read More »Promising new approach to reducing plaque in arteries
Using single cell RNA-seq analysis, researchers showed that TGFβ induced inflammation in endothelial cells in mouse models. In a new Yale-led study, investigators have revealed previously...
Read More »MIT scientists use RNA Bind-n-Seq to characterize the binding preferences of more than 70 human RNA-binding proteins
Thanks to continued advances in genetic sequencing, scientists have identified virtually every A, T, C, and G nucleotide in our genetic code. But to fully understand how the human genome encodes us, we need to go...
Read More »End-enriched RNA-sequencing reveals evolutionary convergence of pathway-specific enzyme expression stoichiometry
Coexpression of proteins in response to pathway-inducing signals is the founding paradigm of gene regulation. However, it remains unexplored whether the relative abundance of co-regulated proteins...
Read More »Single-cell RNA-seq could play a key role in personalized medicine
Researchers at MIT and Linköping University discuss the potential of single-cell RNA sequencing (scRNA-seq) to empower clinical implementation of personalized medicine. On the basis of work to date, they emphasize applications in cancer. Nevertheless, the underlying problems and solutions should be ...
Read More »Making single-cell RNA sequencing widely available
Portable tool could help scientists learn more about cells’ roles in many diseases. by Anne Trafton | MIT News Office Sequencing messenger RNA molecules from individual cells offers a glimpse into the lives of those cells, revealing what they’re doing ...
Read More »Featured RNA-Seq Job – Research Technician II
Description: The Shalek Lab (http://shaleklab.com, MIT, Broad Institute, and Ragon Institute) in collaboration with the Walker Lab (http://www.ragoninstitute.org/portfolio-item/walker-lab/, Ragon Institute) has an opening for a highly motivated Research Technician to assist in a global profiling of the immune system in acute ...
Read More »Featured RNA-Seq Job – Associate Computational Biologist – Transcriptomics
Specialty: Computational Biology Program: Cancer Genome Analysis Job Description: The Broad Institute of MIT & Harvard is looking to hire an exceptional candidate to join the team leading data production and analyses for the Genotype-Tissue Expression Consortium (commonfund.nih.gov/GTEx and gtexportal.org). The goal of ...
Read More »Tracing a cellular family tree with single-cell RNA-Seq
New technique allows tracking of gene expression over generations of cells as they specialize. To track the family history for a single cell, researchers engineered a microfluidic device that traps first an individual cell and then all of its descendants. ...
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