Antibiotic resistance is rising at disturbing rates and contributes to the deaths of millions of people yearly. Antibiotic resistant infections disproportionately affect those with immunocompromising conditions...
Read More »Improving diagnostic yield of exome sequencing with RNA sequencing
The diagnostic yield of exome and genome sequencing remains low (8-70%), due to incomplete knowledge on the genes that cause disease. To improve this, University of Groningen researchers use RNA-seq data from 31,499 samples to predict...
Read More »Routine RNA sequencing of FFPE specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions
Molecular markers have become pivotal in brain tumor diagnostics. Mutational analyses by targeted next-generation sequencing of DNA and array-based DNA methylation assessment with copy number analyses are increasingly being used in routine...
Read More »Clinical utility of RNA sequencing-based testing for thyroid cancer diagnosis and treatment
Challenges involved in the management of thyroid nodules include: Differentiating benign from malignant thyroid nodules when cytopathology results are indeterminate; determining the extent of initial thyroid surgery needed; and identifying targeted treatments for patients with thyroid cancers that do not ...
Read More »RNA-Seq shows pesticides found to alter gene expression in pollinating bees
Scientists are urging for improved regulation on pesticides after finding that they affect genes in bumblebees, according to research led by Queen Mary University of London in collaboration with Imperial College London. For the first time...
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