Why is it that some COVID-19 patients become extremely ill and die, while others experience only mild symptoms? The molecular underpinnings of...
Read More »Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation
Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification. However, it is not fully understood how individual stem cells exit the pluripotent state and transition towards their ...
Read More »SinQC – Quality Control of Single-cell RNA-Seq
Single-cell RNA-seq (scRNA-seq) is emerging as a promising technology for profiling cell-to-cell variability in cell populations. However, the combination of technical noise and intrinsic biological variability makes detecting technical artifacts in scRNA-seq samples particularly challenging. Proper detection of technical artifacts ...
Read More »NSF funds RNA-Seq of “precocious cells”
MADISON — Anthony Gitter remembers the mental spark when listening to a recent talk about the discovery of so-called “precocious cells” — a tiny group of cells that lead a furious advance charge against infection. “What really struck me was ...
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