Circular RNAs (circRNAs) act through multiple mechanisms via their sequence features to fine-tune gene expression networks. Due to overlapping sequences with linear cognates, identifying internal...
Read More »DeePlexiCon – molecular barcoding of native RNAs using nanopore sequencing and deep learning
Nanopore sequencing enables direct measurement of RNA molecules without conversion to cDNA, thus opening the gates to a new era for RNA biology...
Read More »Improved nanopore read accuracy enables single-cell RNA sequencing
High-throughput short-read sequencing has revolutionized how transcriptomes are quantified and annotated. However, while Illumina short-read sequencers can be used to analyze entire transcriptomes down to the level of individual splicing events with great accuracy, they fall short of analyzing how ...
Read More »Highly parallel direct RNA sequencing on an array of nanopores
Sequencing the RNA in a biological sample can unlock a wealth of information, including the identity of bacteria and viruses, the nuances of alternative splicing or the transcriptional state of organisms. However, current methods have limitations due...
Read More »RNA-Seq Blog – Poll Results
We asked: Will the error rate issues with nanopore sequencing eventually be solved? How interesting that almost a third of you believe their are problems that cannot be overcome, even though there are several companies devoting significant resources toward development ...
Read More »Reducing error rates in third-generation sequencing technology
Nanopore DNA sequencing via transverse current has emerged as a promising candidate for third-generation sequencing technology. It produces long read lengths which could alleviate problems with assembly errors inherent in current technologies. However, the high error rates of nanopore sequencing ...
Read More »Next Generation Sequencing (NGS) Market – Global Forecast to 2020
Next Generation Sequencing (NGS) Market by Platforms (Illumina HiSeq, MiSeq, HiSeqX Ten, NextSeq 500,Thermo Fisher Ion Proton/PGM), Bioinformatics (Exome Sequencing, RNA-Seq, ChIP-Seq), Technology (SBS, SMRT) & by Application (Diagnostics, Personalized Medicine) – Global Forecast to 2020 The next generation sequencing ...
Read More »Roche Invests in Sequencing Startup Stratos Genomics; Will Help Develop Nanopore Technology
from GenomeWeb NEW YORK (GenomeWeb) — Roche said today that it has made a strategic investment in nanopore sequencing startup Stratos Genomics and is collaborating to further develop the firm’s sequencing chemistry. Last month, Seattle-based Stratos disclosed that it had ...
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