Tag Archives: nature biotechnology

Despite its importance, scientists still do not understand all of the different cell types that make up the brain. A group of researchers from Baylor College of Medicine (Drs. Andreas and Kimberley Tolias’ laboratories), the Karolinska Institutet (Dr. Rickard Sandberg’s ...

Highlights New method improves single-cell genomics analyses; Method clarifies the true differences and similarities between cells by modelling relatedness and removing confounding variables; Scientists can use known molecular pathways to better understand cancer cells, differentiation processes and the pathogenesis of ...

from Harvard Univeristy by By SUE McGREEVEY New method identifies genome-wide off-target effects of CRISPR-Cas Harvard Medical School investigators at Massachusetts General Hospital have developed a method for detecting unwanted DNA breaks—across the entire genome of human cells—induced by the ...

from Genetic Engineering News RNA sequencing (RNA-seq), a means of depicting the transcriptome, is being used with increasing frequency to characterize a growing array of conditions—everything from prenatal birth defects to disorders of the elderly. Yet the technique, which is ...

E. Aubrey Thompson, Ph.D., Mayo Clinic in Florida JACKSONVILLE, Fla. — Physicians envision a future in which genomic data from patients is heavily used to manage care — but experts have questioned the accuracy and reliability of these analyses. Now, ...

RNA-sequencing data analysis method BitSeq developed by Academy Research Fellow Antti Honkela?s research group and University of Manchester researchers has been found to be the most accurate gene transcript expression estimation method in a large international assessment. The method is ...

from Weill Cornell Medical College News The many different approaches used to sequence RNA, even severely degraded RNA, can produce relatively similar results, a finding that should reassure patients, physicians and scientists faced with a variety of new technologies that ...

Writing in Science, Lee et al. report an exciting first step toward combining some of the best aspects of both methods to sequence RNA in single cells in situ. Their approach, called fluorescence in situ RNA sequencing (FISSEQ), effectively treats ...

“Sailfish” Method Could Pay Dividends as Genomic Medicine Expands Contact: Byron Spice  / 412-268-9068  / bspice@cs.cmu.edu PITTSBURGH—With gene expression analysis growing in importance for both basic researchers and medical practitioners, researchers at Carnegie Mellon University and the University of Maryland ...

ZENBU, a new, freely available bioinformatics tool developed at the RIKEN Center for Life Science Technology in Japan, enables researchers to quickly and easily integrate, visualize and compare large amounts of genomic information resulting from large-scale, next-generation sequencing experiments. Next-generation ...