Network inference provides a global view of the relations existing between gene expression in a given transcriptomic experiment (often only for a...
Read More »BoolFilter – an R package for estimation and identification of partially-observed Boolean dynamical systems
Gene regulatory networks govern the function of key cellular processes, such as control of the cell cycle, response to stress, DNA repair mechanisms, and more. Boolean networks have been used successfully in modeling gene regulatory networks. In the Boolean network ...
Read More »BRANE Clust – Cluster-Assisted Gene Regulatory Network Inference Refinement
Discovering meaningful gene interactions is crucial for the identification of novel regulatory processes in cells. Building accurately the related graphs remains challenging due to the large number of possible solutions from available data. Nonetheless, enforcing a priori on the graph ...
Read More »Modeling of gene regulatory networks from RNA-Seq data
Systems biology is a research area which aims to understand living systems as a whole, instead of focusing on single biological entities. Gene regulatory network inference is a systems biology approach which predicts interactions between genes with the help of ...
Read More »BRANE Cut – biologically-related a priori network enhancement with graph cuts for gene regulatory network inference
Inferring gene networks from high-throughput data constitutes an important step in the discovery of relevant regulatory relationships in organism cells. Despite the large number of available Gene Regulatory Network inference methods, the problem remains challenging: the underdetermination in the space ...
Read More »Dual RNA-Seq enables computational prediction of molecular pathogen-host interactions
Inference of inter-species gene regulatory networks based on gene expression data is an important computational method to predict pathogen-host interactions (PHIs). Both the experimental setup and the nature of PHIs exhibit certain characteristics. First, besides an environmental change, the battle ...
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