UCLA researchers performed RNA sequencing on 40,000 cells to create a high-resolution single-cell gene expression atlas of developing human cortex, providing the first single-cell characterization of previously uncharacterized cell types, including human subplate neurons, comparisons with bulk tissue, and systematic ...
Read More »RNA-Seq confirms a single population of stem cells contributes to lifelong hippocampal neurogenesis
RNA-seq and ATAC-seq analyses were used to confirm that all the cells in the lineage had a common molecular signature and the same developmental dynamics. Scientists once thought that mammals entered adulthood with all of the neurons they would ever ...
Read More »Div-Seq – A single nucleus RNA-Seq method reveals dynamics of rare adult newborn neurons in the CNS
Transcriptomes of individual neurons provide rich information about cell types and dynamic states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, because isolation from dense adult tissue is challenging, and markers for each phase are ...
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