Tag Archives: neurons

A collaborative team from UConn Storrs and The Jackson Laboratory for Genomic Medicine characterized neuron diversity in the lateral hypothalamic area (LHA), a critical coordinator of fundamental...

A team of researchers at Baylor College of Medicine, the Texas Heart Institute and Texas Children’s Hospital has developed a powerful new approach to understand the formation of new neurons in the mammalian adult brain. Published in the journal...

The classification of neurons into distinct types is an ongoing effort aimed at revealing and understanding the diversity of the components of the nervous system.

RNA is unique among all biomolecules as it can be both information-storing and enzymatic. These features are tightly linked to its structure, in which base-pairing interactions give rise to a highly...

Single-cell RNA sequencing offers a promising opportunity for probing cell types mediating specific behavioral functions and the underlying molecular programs. However, this has been hampered by a long-standing issue in transcriptional profiling of dissociated cells, specifically the transcriptional perturbations that ...

Efficient isolation of specific, intact, living neurons from the adult brain is problematic due to the complex nature of the extracellular matrix consolidating the neuronal network. Here, researchers from the RIKEN Institute present significant improvements to the protocol for isolation ...

A team of researchers has developed the first scalable method to identify different subtypes of neurons in the human brain. The research lays the groundwork for “mapping” the gene activity in the human brain and could help provide a better ...

Single-cell sequencing methods have emerged as powerful tools for identification of heterogeneous cell types within defined brain regions. Application of single-cell techniques to study the transcriptome of activated neurons can offer insight into molecular dynamics associated with differential neuronal responses ...

Transcriptomes of individual neurons provide rich information about cell types and dynamic states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, because isolation from dense adult tissue is challenging, and markers for each phase are ...

(a) Experimental workflow started with the isolation, sectioning and microdissection of the primary visual cortex from a transgenic mouse. The tissue samples were converted into a single-cell suspension, single cells were isolated by FACS, poly(A)-RNA from each cell was reverse ...