Tag Archives: next-generation sequencing

The three prime untranslated region (3′-UTR) is known to play a pivotal role in modulating gene expression by determining the fate of mRNA...

Dogs with X-linked hereditary nephropathy (XLHN) have a glomerular basement membrane defect that leads to progressive juvenile-onset renal failure. Their disease is analogous to Alport syndrome in humans, and they also serve as a good model of progressive chronic kidney ...

Quantitative analysis of next-generation sequencing (NGS) data requires discriminating duplicate reads generated by PCR from identical molecules that are of unique origin. Typically, PCR duplicates are identified as sequence reads that align to the same genomic coordinates using reference-based alignment. ...

Posttranscriptional modifications of RNA bases are found not only in many noncoding RNAs but also have recently been identified in coding (messenger) RNAs as well. They require complex and laborious methods to locate, and many still lack methods for localized ...

OmniSeq Inc scientists have developed a next-generation sequencing assay to quantify biomarkers of the host immune response in formalin-fixed, paraffin-embedded (FFPE) tumor specimens. This assay aims to provide clinicians with a comprehensive characterization of the immunological tumor microenvironment as a ...

Fusion genes play an important role in the tumorigenesis of many cancers. Next-generation sequencing (NGS) technologies have been successfully applied in fusion gene detection for the last several years, and a number of NGS-based tools have been developed for identifying ...

RNA-Seq Viewer is a web application that enables users to visualize genome-wide expression data from NCBI’s Sequence Read Archive (SRA) and Gene Expression Omnibus (GEO) databases. The application prototype was created by a small team during a three-day hackathon facilitated ...

Pharmacogenomics has revealed compelling genetic signals associated with variability in drug response. Gene expression studies represent an additional approach to identify candidate genes accounting for drug response variability. Researchers from the University of Florida discuss insights that might be gained through analysis of ...

Detecting sources of bias in transcriptomic data is essential to determine signals of Biological significance. Researchers from the University of London outline a novel method to detect sequence specific bias in short read Next Generation Sequencing data. This is based ...

NantHealth, Inc., a next-generation, evidence-based, personalized healthcare company, announced that it has entered into an agreement for GPS Cancer, the leading proteogenomic molecular test that helps guide treatment strategies including choice of standard chemotherapy for oncologists, with Asia Genomics, a leading provider and distributor ...