A team led by researchers at the National Heart Lung and Blood Institute sequenced over 700 individuals from the Drosophila Genetic Reference Panel with the goal of identifying the optimal analysis approach for the detection of differential gene expression among ...
Read More »Comprehensive assembly of “unmappable” reads from human RNA-Seq data
Crucial parts of the genome including genes encoding microRNAs and noncoding RNAs went unnoticed for years, and even now, despite extensive annotation and assembly of the human genome, RNA-sequencing continues to yield millions of unmappable and thus uncharacterized reads. Here, ...
Read More »RNA-Seq reveals HPV contamination of endometrial cancer samples in The Cancer Genome Atlas database
High-throughput RNA-Sequencing followed by computational analysis has vastly accelerated the identification of viral and other pathogenic sequences in clinical samples, but cross-contamination during the processing of the samples remain a major problem that can lead to erroneous conclusions. Researchers at ...
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