Tag Archives: NIEHS

The Cancer Genome Atlas (TCGA) has generated comprehensive molecular profiles. Researchers at the National Institute of Environmental Health Sciences aimed to identify a set of genes whose expression patterns can distinguish diverse tumor types. Those features may serve as biomarkers ...

Over-representation analysis (ORA) detects enrichment of genes within biological categories. Gene Ontology (GO) domains are commonly used for gene/gene-product annotation. When ORA is employed, often times there are hundreds of statistically significant GO terms per gene set. Comparing enriched categories ...

Most genes in mammals generate several transcript isoforms that differ in stability and translational efficiency through alternative splicing. Such alternative splicing can be tissue- and developmental stage-specific, and such specificity is sometimes associated with disease. Thus, detecting differential isoform usage ...