Current methods for determining RNA structure with short-read sequencing cannot capture most differences between distinct transcript isoforms. Researchers at A*STAR, Singapore present RNA structure analysis using nanopore sequencing...
Read More »Improved structural variant interpretation for hereditary cancer susceptibility using long-read sequencing
Structural variants (SVs) may be an underestimated cause of hereditary cancer syndromes given the current limitations of short-read next-generation sequencing. Here researchers from the University of...
Read More »Epitranscriptomics – a rapidly developing field
Modified nucleotides in mRNA are an essential addition to the standard genetic code of four nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics examines...
Read More »G42 and ONT co-develop ultra-scalable RNA sequencing based solution for COVID-19 detection
End-to-end solution will enable mass/on-demand screening to support the re-opening of global economies. Group 42 (G42), a leading AI and Cloud Computing company based in the United Arab Emirates, and Oxford Nanopore Technologies, an advanced sequencing technology company based in the United ...
Read More »Oxford Nanopore Launches Flongle for Rapid, Smaller DNA/RNA Sequencing Tests in Any Environment
Oxford Nanopore has today made Flongle starter packs available to purchase https://store.nanoporetech.com/flongle.html, after initial testing in an early-access programme. Flongle introduces a new paradigm of smaller, on-demand DNA or RNA sequencing tests, with the potential to transform a range of ...
Read More »Oxford Nanopore introduces new cDNA kits for transcriptome sequencing
Oxford Nanopore has launched new ‘109’ cDNA Kits for its real-time, scalable sequencing technology. The new kits provide high throughput whilst generating complete sequences of full-length cDNA strands, with a low input option of just 1ng PolyA+ RNA. The new ...
Read More »A handheld DNA/RNA sequencer achieves $1000 genome
Scientists have assembled the most complete human genome to be mapped with a single technology using a new pocket-size portable DNA sequencer, which they say could one day make genome mapping quick and simple enough to do at home. Using ...
Read More »Nanopore Long-Read RNAseq Reveals Widespread Transcriptional Variation
Understanding gene regulation and function requires a genome-wide method capable of capturing both gene expression levels and isoform diversity at the single cell level. Short-read RNAseq, while the current standard for gene expression quantification, is limited in its ability to ...
Read More »“We see single-cell RNA-seq as the right way to do gene expression analysis”
Some sequencing applications, such as the detection of single nucleotide polymorphisms, can be managed with short-read technology. Other applications, such as the detection of structural variants, may demand long-read technology, and some applications, such as the assembly of a new ...
Read More »Oxford Nanopore’s Software Side
from BioIT World by By Aaron Krol Oxford Nanopore Technologies has built an impressive hardware operation from its home in the UK. Its MinION device, a handheld DNA sequencer smaller than a remote control, once seemed like the stuff of ...
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