TGen and HonorHealth investigators suggest this granular analysis could lead to better treatments for pancreatic cancer patients Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and...
Read More »TCGA RNA-seq data reaveals a five-microRNA signature for survival prognosis in pancreatic adenocarcinoma
Novel biomarkers for pancreatic adenocarcinoma are urgently needed because of its poor prognosis. Here, by using The Cancer Genome Atlas (TCGA) RNA-seq data, researchers from the Huazhong University of...
Read More »A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression
Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of formalin-fixed, paraffin-embedded (FFPE) cancer samples from patients represent a rich resource for linking molecular signatures to clinical data. However, performing NGS ...
Read More »Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes
The ability to perform comprehensive profiling of cancers at high resolution is essential for precision medicine. Liquid biopsies using shed exosomes provide high-quality nucleic acids to obtain molecular characterization, which may be especially useful for visceral cancers that are not ...
Read More »RNA-Seq enables discovery of potential biomarker – SSRs (simple sequence repeats)
The recent exponential increase in the number of next generation sequencing studies provides a new source of data for the discovery of functional genomics based markers. RNA-seq and small RNA-seq provide a new source for the discovery of differentially expressed ...
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