Changes in the blood-based RNA transcriptome have the potential to inform biomarkers of Parkinson’s disease (PD) progression. Researchers from the Parkinson Progression Marker Initiative sequenced a...
Read More »Researchers use RNA Sequencing to track down molecular signals of Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disease in the world, yet little is known about its causes and progression...
Read More »Grant will fund single-cell RNA sequencing study of link between senescence and Parkinson’s disease
A collaborative team between the University of Minnesota Medical School and Van Andel Institute (VAI) will soon begin a $6.2 million study that seeks to define the molecular linkages between aging and Parkinson’s disease — an approach for new treatment ...
Read More »Mapping cell types by single cell sequencing in a Parkinson’s disease cell therapy model
Many severe symptoms in Parkinson’s disease are caused by the degeneration of the brain’s dopamine neurons. Transplantation of stem cell-derived dopamine neurons to patients with Parkinson’s disease is a therapeutic approach that is getting close to...
Read More »Massive Parkinson’s database gets boost of RNA sequencing data
A team of experts at the Keck School of Medicine of USC, in collaboration with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), has just added a crucial new element – RNA sequencing...
Read More »seqclusterViz – visualization of the small RNA transcriptome
The study of small RNAs provides us with a deeper understanding of the complexity of gene regulation within cells. Of the different types of small RNAs, the most important in mammals are miRNA, tRNA fragments and piRNAs. Using small RNA-seq ...
Read More »Using RNA-Seq to look beyond the brain in Parkinson’s disease
from BMC Series Blog by Anna Clark Parkinson’s disease (PD) is a chronic, neurodegenerative disorder that affects 1% of the population over the age of 60. PD is considered to be a movement disorder; the cardinal signs of the disease ...
Read More »RNA-Seq collaboration leads to new treatment for Parkinson’s disease
In two articles published in Cell Stem Cell, scientists from Karolinska Institutet and Lund University present results that warrant a modification of the protocol for making dopamine. The new protocol is now ready for clinical use. One of the challenges ...
Read More »Transcriptomics identifies genes and signaling pathways that may regulate neurodegeneration
Society for Experimental Biology and Medicine Massive elimination of neurons is a critical aspect of normal nervous system development but also represents a defining feature of neurodegenerative pathologies, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. ...
Read More »