Tag Archives: pathogen

The use of broad-spectrum detection methods identified pathogens in more than one-third of children hospitalized with community-acquired pneumonia without a previously identified cause. “Pathogens vary by age but viruses are the most common cause of CAP in children less than ...

Host-pathogen interactions are exceedingly complex because they involve multiple host tissues, often occur in the context of normal microflora, and can span diverse microenvironments. Although decades of gene expression studies have provided detailed insights into infection processes, technical challenges have ...

Global transcriptomic analysis via RNA-seq is often hampered by the high abundance of ribosomal (r)RNA in bacterial cells. To remove rRNA and enrich coding sequences, subtractive hybridization procedures have become the approach of choice prior to RNA-seq, with their efficiency ...

The ability to simultaneously characterize the bacterial and host expression programs during infection would facilitate a comprehensive understanding of pathogen-host interactions. Although RNA sequencing (RNA-seq) has greatly advanced our ability to study the transcriptomes of prokaryotes and eukaryotes separately, limitations ...

An invasive bacterium must adapt to the environment of the host cell while the host cell reacts to the invader. However, the analysis of transcriptomes to understand changes in host and pathogen gene expression has typically been applied to a ...

Bacteria express many small RNAs for which the regulatory roles in pathogenesis have remained poorly understood due to a paucity of robust phenotypes in standard virulence assays. Here, researchers from the University of Würzburg used a generic ‘dual RNA-seq’ approach ...

Researchers from CSIRO Health and Biosecurity have published findings that start to explain how mosquitoes respond to viral infections. Using an RNA-sequencing approach, they identified a number of genes from multiple cellular pathways that play integral roles in protecting mosquitoes from ...

Genome-scale analysis of host-pathogen interactions – University of Technology Sydney We are seeking a PhD student to apply leading-edge bioinformatics analysis methods to decipher the interactions of the obligate intracellular human pathogen, Chlamydia trachomatis, with its host cell. This is ...