In vivo transcriptional analyses of microbial pathogens are often hampered by low proportions of pathogen biomass in host organs, hindering the coverage of full pathogen transcriptome. Researchers at University Hospital Lausanne, aimed to address the transcriptome profiles of Candida albicans, ...
Read More »Complex in vivo RNA-Seq of a Bacterial Pathogen
Researchers at Umeå University recently found that Yersinia pseudotuberculosis can be used as a model of persistent bacterial infections. They performed in vivo RNA-seq of bacteria in small cecal tissue biopsies at early and persistent stages of infection to determine ...
Read More »High-throughput sequencing for the study of bacterial pathogen biology
A revolution in sequencing technologies in recent years has led to dramatically increased throughput and reduced cost of bacterial genome sequencing. An increasing number of applications of the new technologies are providing broad insights into bacterial evolution, epidemiology, and pathogenesis. ...
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