Researchers at MIT and Linköping University discuss the potential of single-cell RNA sequencing (scRNA-seq) to empower clinical implementation of personalized medicine. On the basis of work to date, they emphasize applications in cancer. Nevertheless, the underlying problems and solutions should be ...
Read More »Cofactor Genomics Announces $18M Funding Round to Bring RNA to Precision Medicine
Cofactor Genomics, developer of a leading platform for RNA sequencing and expression analysis, today announced $18M in financing led by Menlo Ventures with major participation from existing investor Data Collective (DCVC) and new investor Ascension Ventures, and participation from existing ...
Read More »Comprehensive sequencing program shows promise of precision medicine for advanced cancer
DNA, RNA sequencing of 500 patients reveals potential treatment targets, deeper understanding of metastatic cancer The average metastatic cancer has more genetic mutations than are seen in early stage tumors, a new study finds. What that means: To make precision ...
Read More »UCLA Researchers introduce “RADIOTRANSCRIPTOMICS”- A synergy of imaging and transcriptomics in clinical assessment
Recent advances in quantitative imaging and “omics” technology have generated a wealth of mineable biological “big data”. With the push towards a P4 “predictive, preventive, personalized, and participatory” approach to medicine, researchers began integrating complementary tools to further tune existing ...
Read More »New brain cancer coalition announces precision medicine study
Philadelphia Coalition for a Cure (PC4C), a newly launched cooperative clinical diagnostics and research initiative announced that it will collaborate in a study together with Children’s Hospital of Orange County (CHOC) directed to the study and diagnosis of adult and pediatric ...
Read More »Precision medicine experts emphasize the need to “move beyond” DNA sequencing to much more pointed RNA-sequencing technology
from Fierce Healthcare by Evan Sweeney – Precision medicine efforts have only scratched the surface of cancer treatment transformation, and experts at one of the nation’s leading oncology centers say continued success will rely on advancements in genomic sequencing technology, ...
Read More »Researchers use RNA-Seq to uncover gene expression markers that predict drug-specific response
Three gene expression signatures can help rheumatologists predict which patients are more likely to respond to tumor necrosis factor inhibitors (TNFi) or B-cell depletion therapies in patients with moderate to severe rheumatoid arthritis, according to new research findings presented this ...
Read More »Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance
Tumor heterogeneity has been compared with Darwinian evolution and survival of the fittest. The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations represents a considerable challenge to tumor therapy, since all genetically and phenotypically different subpopulations have to ...
Read More »Ultrafast RNA-Seq Analysis Tool Could Change How Infectious Diseases Are Diagnosed
SALT LAKE CITY-Scientists at the University of Utah School of Medicine, ARUP Laboratories, and IDbyDNA, Inc., have developed ultra-fast, meta-genomics analysis software called Taxonomer that dramatically improves the accuracy and speed of pathogen detection. In a paper published today in ...
Read More »Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes
The ability to perform comprehensive profiling of cancers at high resolution is essential for precision medicine. Liquid biopsies using shed exosomes provide high-quality nucleic acids to obtain molecular characterization, which may be especially useful for visceral cancers that are not ...
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