Selective and flexible depletion of problematic sequences from RNA-seq libraries at the cDNA stage

June 3, 2014 Leave a comment 6,701 Views

A major hurdle to transcriptome profiling by deep-sequencing technologies is that abundant transcripts, such as rRNAs, can overwhelm the libraries, severely reducing transcriptome-wide coverage. Methods for depletion of such unwanted sequences typically require treatment of RNA samples prior to library ...

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