Tag Archives: python

With the advent of Next-Generation Sequencing (NGS) technologies, numerous data is being generated every day, however, analysis remains a big hurdle to efficiently use the technology as this data requires complex multi-step processing and...

High-throughput sequencing often provides a foundation for experimental analyses in the life sciences. For many such methods, an intermediate layer of bioinformatics data analysis is the genomic signal track constructed by short read mapping...

The Parasite genomics team at the Wellcome Trust Sanger Institute are seeking a talented Bioinformatician to work on WormBase ParaSite (parasite.wormbase.org), a portal for parasitic worm genomics. Parasitic worms are responsible for more than one billion human infections globally and have a ...

Sequencing of RNA provides the possibility to study an individual’s transcriptome landscape and determine allelic expression ratios. Single-molecule protocols generate multi-kilobase reads longer than most transcripts allowing sequencing of complete haplotype isoforms. This allows partitioning the reads into two parental ...

Grafting of cell lines and primary tumours is a crucial step in the drug development process between cell line studies and clinical trials. AstraZeneca researchers have developed disambiguate, a program for computationally separating the sequencing reads of two species derived ...

Next-generation sequencing (NGS) informs many biological questions with unprecedented depth and nucleotide resolution. These assays have created a need for analytical tools that enable users to manipulate data nucleotide-by-nucleotide robustly and easily. Furthermore, because many NGS assays encode information jointly ...

Circular RNAs (circRNAs) belong to a recently re-discovered species of RNA that emerge during RNA maturation through a process called back-splicing. A downstream 5’ splice site is linked to an upstream 3’ splice site to form a circular transcript instead ...

BD (Becton, Dickinson and Company) (Menlo Park, CA) Description: Cellular Research, Inc., a biotechnology research and development company founded in 2011 by innovators from Silicon Valley and Stanford University, was recently acquired by Becton Dickinson and has become an integral ...

The growing recognition of the importance of splicing in eukaryotes, together with rapidly accumulating RNA-sequencing data, demand robust high-throughput approaches, which efficiently analyze experimentally derived whole-transcriptome splice profiles. Researchers from The George Washington University have developed a computational approach, called ...

A large choice of tools exists for many standard tasks in the analysis of high-throughput sequencing (HTS) data. However, once a project deviates from standard workflows, custom scripts are needed. Researchers at the European Molecular Biology Laboratory present HTSeq, a ...