Tag Archives: R package

edgeRun – an R package for sensitive, functionally relevant differential expression discovery using an unconditional exact test

rna-seq

Next-generation sequencing platforms for measuring digital expression such as RNA-Seq are displacing traditional microarray-based methods in biological experiments. The detection of differentially expressed genes between groups of biological conditions has led to the development of numerous bioinformatics tools, but so ...

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Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures

There is a critical need for standard approaches to assess, report and compare the technical performance of genome-scale differential gene expression experiments. Here, an international team led by researchers at the NIST assess technical performance with a proposed standard ‘dashboard’ ...

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IUTA – a tool for effectively detecting differential isoform usage from RNA-Seq data

rna-seq

Most genes in mammals generate several transcript isoforms that differ in stability and translational efficiency through alternative splicing. Such alternative splicing can be tissue- and developmental stage-specific, and such specificity is sometimes associated with disease. Thus, detecting differential isoform usage ...

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