MicroRNAs (miRNAs) have been described to simultaneously inhibit hundreds of targets, albeit to a modest extent. It was recently proposed that there could exist more specific, exceptionally strong binding to a subgroup of targets. However, it is unknown, whether this ...
Read More »Featured RNA-Seq Job – Computational Biologist
A Computational Biologist or Bioinformatician position is offered by the laboratory of Dr. Maite Huarte of CIMA research institute in Pamplona, Spain. The position is funded by the European Research Council (ERC) with the possibility of at least a 5-year ...
Read More »New RNA-seq approaches for the study of bacterial pathogens
Understanding how bacteria cause disease requires knowledge of which genes are expressed and how they are regulated during infection. While RNA-seq is now a routine method for gene expression analysis in bacterial pathogens, the past years have also witnessed a ...
Read More »Identifying RBP Targets with RIP-seq
One of the challenges to assess the impact of RBPs on posttranscriptional gene regulation is identifying and quantifying the RNA and protein components of ribonucleoprotein complexes (RNPs) in a cellular context. The human genome is estimated to contain 1542 RBPs. ...
Read More »RNA Bioinformatics – New RNA-Seq Protocols from Methods in Molecular Biology
RNA Bioinformatics Edited by Ernesto Picardi ISBN: 978-1-4939-2290-1 (Print) 978-1-4939-2291-8 (Online) Analysis of High-Throughput RNA Sequencing Data Quality Control of RNA-Seq Experiments Xing Li, Asha Nair, Shengqin Wang, Liguo Wang Pages 137-146 Accurate Mapping of RNA-Seq Data Kin Fai Au ...
Read More »RIP-seq analysis of eukaryotic Sm proteins identifies three major categories of Sm-containing ribonucleoproteins
Sm proteins are multimeric RNA-binding factors, found in all three domains of life. Eukaryotic Sm proteins, together with their associated RNAs, form small ribonucleoprotein (RNP) complexes important in multiple aspects of gene regulation. Comprehensive knowledge of the RNA components of ...
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