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N6-methyladenosine (m6A) is an abundant RNA modification that plays critical roles in RNA regulation and cellular function. Global m6A...
Read More »scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells
meCLICK-Seq – a substrate-hijacking and RNA degradation strategy for the study of RNA methylation
The fates of RNA species in a cell are controlled by ribonucleases, which degrade them by exploiting the universal structural 2′-OH group. This phenomenon plays a key role in numerous transformative...
Read More »DRME – count-based differential RNA methylation analysis at small sample size scenario
Differential methylation, which concerns difference in the degree of epigenetic regulation via methylation between two conditions, has been formulated as a beta or beta-binomial distribution to address the within-group biological variability in sequencing data. However, a beta or beta-binomial model ...
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