Tag Archives: RNA modifications

The study of RNA modifications in large clinical cohorts can reveal relationships between the epitranscriptome and human diseases, although this is especially challenging. Researchers from the National University of Singapore have developed ModTect, a statistical framework to identify RNA modifications ...

In addition to four nucleotides in mRNA modified nucleotides are an essential addition to the standard genetic code in eukaryotes and prokaryotes. Epitranscriptomics has emerged as a new field to study nucleotide modifications in mRNA and examine their impact on ...

Reverse transcriptase (RT) enzymes are indispensable tools for interrogating diverse aspects of RNA metabolism and transcriptome composition. Due to the growing interest in sequence and...

An epitranscriptome is a set of functionally appropriate RNA modifications. There are nearly one hundred known modifications of RNA; the most common modification in internal mRNA is...

Combination of reverse transcription (RT) and deep sequencing has emerged as a powerful instrument for the detection of RNA modifications, a field that has seen a recent surge in activity because of its importance in gene regulation. Recent studies yielded ...

Although more than 100 different types of RNA modifications have been characterized across all living organisms, surprisingly little is known about the modified positions and their functions. Recently, various high-throughput modification sequencing methods have been developed to identify diverse post-transcriptional ...