Tag Archives: rna splicing

Although RNA-Seq data provide unprecedented isoform-level expression information, detection of alternative isoform regulation (AIR) remains difficult, particularly when working with an incomplete transcript annotation. Researchers at the National Human Genome Research Institute introduce JunctionSeq, a new method that builds on the ...

Understanding the occurrence and regulation of alternative splicing (AS) is a key task towards explaining the regulatory processes that shape the complex transcriptomes of higher eukaryotes. With the advent of high-throughput sequencing of RNA (RNA-Seq), the diversity of AS transcripts ...

New approach to quantifying gene “read-outs” reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases PHILADELPHIA— A new way of mapping the “transcriptome” — the collection of RNA read-outs that are expressed by a cell’s active ...

Hiring department – Icmb-PI-Lambowitz Monthly salary – $3,750+ depending on qualifications Hours per week – 40.00 Standard from 800AM to 500PM Posting number – 15-05-07-01-0708 Job Status – Open FLSA status – Exempt Earliest Start Date – Immediately Position Duration ...

Viral infection causes multiple forms of human cancer, and HPV infection is the primary factor in cervical carcinomas. Recent single-cell RNA-seq studies highlight the tumor heterogeneity present in most cancers, but virally induced tumors have not been studied. HeLa is ...

Requisition Number 15-0350 Post Date 8/11/2015 Title RESEARCH FELLOW Department Ocular Genomics-Pierce Shift Day Hours Per Week 40 City Boston State MA Description The Ocular Genomics Institute at the Massachusetts Eye and Ear, Harvard Medical School is seeking a talented ...

by JM Kocarnik at FHCRC Alternative splicing of specific genes can contribute to cancer initiation, progression, and metastasis.  With the advent of cancer genome sequencing, it was discovered that many tumor types contain high frequencies of somatic mutations affecting components ...

This lecture explains about the RNA sequencing process and the methods or RNA splicing is explained. It also states the use of RNA sequencing in molecular biology. RNA Sequencing, often known as entire Transcriptome Shotgun Sequencing, is a science that ...

Three principal approaches have been proposed for inferring the set of transcripts expressed in RNA samples using RNA-seq. The simplest approach uses curated annotations, which assumes the transcripts in a sample are a subset of the transcripts listed in a ...

Pre-mRNA splicing is a critical step in eukaryotic gene expression that contributes to proteomic, cellular and developmental complexity. Small nuclear (sn)RNAs are core spliceosomal components, however, the extent to which differential expression of snRNA isoforms regulates splicing is completely unknown. ...