Tag Archives: Science

Are you interested in analysing the expression dynamics in single cell RNAseq data, and estimating the RNA velocity of single cells? This talk (https://youtu.be/EPTgF4EA2zY) introduces the Velocyto package (http://velocyto.org/), winner of the SIB Bioinformatics Awards 2019 in the category Bioinformatics ...

The “RNA world” is not at all hypothetical but rather the biological world we live in (1). For RNA to function within a modern cellular milieu of proteins and DNA, numerous chemical modifications coevolved that help sculpt its interactions (2). ...

Writing in Science, Lee et al. report an exciting first step toward combining some of the best aspects of both methods to sequence RNA in single cells in situ. Their approach, called fluorescence in situ RNA sequencing (FISSEQ), effectively treats ...

Mutations in the mitochondrial genome are associated with multiple diseases and biological processes; however, little is known about the extent of sequence variation in the mitochondrial transcriptome. By ultra-deeply sequencing mitochondrial RNA (>6000×) from the whole blood of ~1000 individuals ...

In multicellular organisms, biological function emerges when heterogeneous cell types form complex organs. Nevertheless, dissection of tissues into mixtures of cellular subpopulations is currently challenging. Researchers at the Weizmann Institute, Israel introduce an automated massively parallel single-cell RNA sequencing (RNA-seq) ...