Sensory neurons are distinguished by distinct signaling networks and receptive characteristics. Thus, sensory neuron types can be defined by linking transcriptome-based neuron typing with the sensory phenotypes. Here researchers from the Shanghai Institutes for Biological Sciences classify somatosensory neurons of ...
Read More »Comparison of Computational Methods for Identification of Allele-Specific Expression based on Next Generation Sequencing Data
Allele-specific expression (ASE) studies have wide-ranging implications for genome biology and medicine. Whole transcriptome RNA sequencing (RNA-Seq) has emerged as a genome-wide tool for identifying ASE, but suffers from mapping bias favoring reference alleles. Two categories of methods are adopted ...
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