The advent of next-generation RNA sequencing (RNA-seq) has greatly advanced transcriptomic studies, including system-wide identification and quantification of mRNA isoforms under various biological conditions. A number of computational methods have been developed to systematically identify mRNA isoforms in a high-throughput ...
Read More »Computational approaches for isoform detection and estimation
The main goal of the whole transcriptome analysis is to correctly identify all expressed transcripts within a specific cell/tissue – at a particular stage and condition – to determine their structures and to measure their abundances. RNA-seq data promise to ...
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