The study of small RNAs provides us with a deeper understanding of the complexity of gene regulation within cells. Of the different types of small RNAs, the most important in mammals are miRNA, tRNA fragments and piRNAs. Using small RNA-seq ...
Read More »A new fragmented ribodepleted TGIRT sequencing method
Comparing the abundance of one RNA molecule to another is crucial for understanding cellular functions but most sequencing techniques can target only specific subsets of RNA. In this study, researchers from the Université de Sherbrooke used a new fragmented ribodepleted TGIRT ...
Read More »A workflow for analysis of small RNA sequencing data
Small RNAs (size 20-30 nt) of various types have been actively investigated in recent years, and their subcellular compartmentalization and relative concentrations are likely to be of importance to their cellular and physiological functions. Comprehensive data on this subset of ...
Read More »DASHR – a database of small human noncoding RNAs
Small non-coding RNAs (sncRNAs) are highly abundant RNAs, typically <100 nucleotides long, that act as key regulators of diverse cellular processes. Although thousands of sncRNA genes are known to exist in the human genome, no single database provides searchable, unified ...
Read More »miRge – A Multiplexed Method of Processing Small RNA-Seq Data to Determine MicroRNA Entropy
Small RNA RNA-seq for microRNAs (miRNAs) is a rapidly developing field where opportunities still exist to create better bioinformatics tools to process these large datasets and generate new, useful analyses. Researchers at Johns Hopkins University School of Medicine have built ...
Read More »plantDARIO – web based quantitative and qualitative analysis of small RNA-seq data in plants
High-throughput sequencing techniques have made it possible to assay an organism’s entire repertoire of small non-coding RNAs (ncRNAs) in an efficient and cost-effective manner. The moderate size of small RNA-seq datasets makes it feasible to provide free web services to ...
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