Tag Archives: spliceosome

Pre-mRNA splicing represents an important regulatory layer of eukaryotic gene expression. In the simple budding yeast Saccharomyces cerevisiae, about one-third of all mRNA molecules undergo splicing, and splicing efficiency is tightly regulated, for example, during meiotic differentiation. S. cerevisiae features ...

About five years ago, it was shown that mutations in genes encoding splicing factors occur frequently in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Splicing, the process by which introns are removed from the pre-messenger RNA and ...