Tag Archives: Stanford University

Comprehensive transcriptome analysis using synthetic long-read sequencing reveals molecular co-association of distant splicing events

rna-seq

Alternative splicing shapes mammalian transcriptomes, with many RNA molecules undergoing multiple distant alternative splicing events. Comprehensive transcriptome analysis, including analysis of exon co-association in the same molecule, requires deep, long-read sequencing. Here we introduce an RNA sequencing method, synthetic long-read ...

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Online games and remote experiments could reduce scientific fraud, cherry-picking

Carnegie Mellon and Stanford researchers advocate massive online laboratories PITTSBURGH—One way to combat the rising level of errors and fraud in life sciences research is through massive online laboratories, which use videogames to engage large numbers of non-professional investigators and ...

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High-Resolution Transcriptome Analysis with Long-Read RNA Sequencing

rna-seq

RNA sequencing (RNA-seq) enables characterization and quantification of individual transcriptomes as well as detection of patterns of allelic expression and alternative splicing. Current RNA-seq protocols depend on high-throughput short-read sequencing of cDNA. However, as ongoing advances are rapidly yielding increasing ...

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