RNA-Seq Blog Transcriptome Research & Industry News
Pioneering new research has made a pivotal breakthrough that dispel concerns that human stem cells could contain cancer-causing mutations...
Read More »RNA sequencing dispels fears human stem cells contain cancer-causing mutations
EMBO Workshop: The Epitranscriptome
The regulation of the transcriptome is key to cellular processes that underpin cell biology, development and tissue function. All classes of cellular RNA are subject to post-transcriptional modification, be it by direct chemical modification, editing or non-templated nucleotide additions. It ...
Read More »Self-assembling manifolds in single-cell RNA sequencing data
Single-cell RNA sequencing has spurred the development of computational methods that enable researchers to classify cell types, delineate developmental trajectories, and measure...
Read More »RNA-Seq enables discovery of ‘kingpin’ stem cells, greater understanding of cancerous tumours
A team of McMaster University researchers has discovered a unique subset of cells within human stem cells that appear to signal how the surrounding cells will develop and grow.The discovery of...
Read More »RNA-Seq confirms a single population of stem cells contributes to lifelong hippocampal neurogenesis
RNA-seq and ATAC-seq analyses were used to confirm that all the cells in the lineage had a common molecular signature and the same developmental dynamics. Scientists once thought that mammals entered adulthood with all of the neurons they would ever ...
Read More »RNA Sequencing leads to stem cell break-through in bone growth
Human stem cells have shown potential in medicine as they can transform into various specialized cell types such as bone and cartilage cells. The current approach to obtain such specialized cells is to subject stem cells to specialized instructive protein ...
Read More »Sniffing out stem cell fates in the nose with single-cell RNA-Seq
Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in a living animal. UC ...
Read More »RNA-Seq collaboration leads to new treatment for Parkinson’s disease
In two articles published in Cell Stem Cell, scientists from Karolinska Institutet and Lund University present results that warrant a modification of the protocol for making dopamine. The new protocol is now ready for clinical use. One of the challenges ...
Read More »Single-cell RNA-Seq supports a role for cancer stem cells in brain tumor growth
Mass. General, Broad Institute team finds strong evidence that cancer stem cells are important drivers of tumors in patients A study analyzing brain tumor genomics on a single-cell level has found evidence that cancer stem cells fuel the growth of ...
Read More »Single-cell transcriptomics reveals the dynamics of lineage commitment of differentiating embryonic stem cells
Gene expression heterogeneity in the pluripotent state of mouse embryonic stem cells (mESCs) has been increasingly well-characterized. In contrast, exit from pluripotency and lineage commitment have not been studied systematically at the single-cell level. Here a team led by researchers ...
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