Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels

August 6, 2014 Comments Off on Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels 5,576 Views

Given increasing numbers of RNA-seq samples in the public domain, researchers at the University of Groningen studied to what extent expression quantitative trait loci (eQTLs) and allele-specific expression (ASE) can be identified in public RNA-seq data while also deriving the ...

Library generation introduces significant biases in RNA-seq data, adding extreme variability to coverage and read-depth

July 2, 2014 Leave a comment 6,765 Views

RNA-seq is a powerful technique for identifying and quantifying transcription and splicing events, both known and novel. However, given its recent development and the proliferation of library construction methods, understanding the bias it introduces is incomplete but critical to realizing ...

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Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels

Library generation introduces significant biases in RNA-seq data, adding extreme variability to coverage and read-depth

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