Allele-specific expression (ASE) refers to the differential abundance of the allelic copies of a transcript. RNA sequencing (RNA-Seq) can provide quantitative estimates of ASE for genes with transcribed polymorphisms. When short-read sequences are aligned to a diploid transcriptome, readmapping ambiguities ...
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Combining single-cell genomics and computational techniques, a research team including Paul Robson, Ph.D., director of single-cell biology at The Jackson Laboratory (JAX), has defined cell-type composition of cancerous cells from 11 colorectal tumors, as well as adjacent noncancerous cells, a ...
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The increasing amount of heterogeneous Next Generation Sequencing (NGS) data generated today necessitates a robust platform for the efficient data storage, management, pre-processing, quality checking, analysis and visualization. Addressing each of these categories is a tremendous undertaking requiring high-level expertise ...
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Narayanan Raghupathy, Ph.D., The Jackson Laboratory April 22, 2014 | 4 p.m. Kinne Library, Morris Building Direct RNA sequencing of genes with polymorphisms can provide quantitative estimates of maternal and paternal alleles’ expression, not just the total gene expression. Narayanan ...
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