Initiatives such as The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) have generated high-quality, multi-platform molecular data from thousands of frozen tumor...
Read More »Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
Clustered heatmaps are the most frequently used graphics for visualization of molecular profiling data in biology. However, they are generally rendered as static, or only modestly interactive, images. Researchers at The University of Texas MD Anderson Cancer Center have now used ...
Read More »Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes
The ability to perform comprehensive profiling of cancers at high resolution is essential for precision medicine. Liquid biopsies using shed exosomes provide high-quality nucleic acids to obtain molecular characterization, which may be especially useful for visceral cancers that are not ...
Read More »The landscape and therapeutic relevance of cancer-associated transcript fusions
Transcript fusions as a result of chromosomal rearrangements have been a focus of attention in cancer as they provide attractive therapeutic targets. To identify novel fusion transcripts with the potential to be exploited therapeutically, researchers from the University of Texas ...
Read More »The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes
Although individual pseudogenes have been implicated in tumour biology, the biomedical significance and clinical relevance of pseudogene expression have not been assessed in a systematic way. Here researchers from the University of Texas MD Anderson Cancer Center generate pseudogene expression ...
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