Tag Archives: Thomas Jefferson University

Transfer RNA fragments (tRFs) are an established class of constitutive regulatory molecules that arise from precursor and mature tRNAs. RNA deep sequencing (RNA-seq) has greatly facilitated the study of tRFs. However, the repeat nature of the tRNA templates and the ...

Isoforms of human miRNAs (isomiRs) are constitutively expressed with tissue- and disease-subtype-dependencies. Researchers from Thomas Jefferson University studied 10 271 tumor datasets from The Cancer Genome Atlas (TCGA) to evaluate whether isomiRs can distinguish amongst 32 TCGA cancers. Unlike previous ...

Researchers from Thomas Jefferson University present “Threshold-seq,” a new approach for determining thresholds in deep-sequencing datasets of short RNA transcripts. Threshold-seq addresses the critical question of how many reads need to support a short RNA molecule in a given dataset ...

Department – Computational Medicine Center Department Website https://cm.jefferson.edu/ Institution – Thomas Jefferson University Philadelphia, PA – United States Application Deadline – Open until filled Position Start Date – Available immediately Job Categories – Post-Doc Academic Fields – Biochemistry & Cellular ...

Researchers at Thomas Jefferson University present rna22, a method for identifying microRNA binding sites and their corresponding heteroduplexes. Rna22 does not rely upon cross-species conservation, is resilient to noise, and, unlike previous methods, it first finds putative microRNA binding sites ...

The production of microRNA isoforms in human tissues depends on a person’s gender, population origin, and race as well as on tissue, disease and disease subtype Researchers at Thomas Jefferson University previously reported that miRNA isoforms in healthy individuals change as ...

Since their discovery in the 1950s, transfer RNAs (tRNAs) have been best known for their role in helping the cell make proteins from messenger RNA templates. However, recent studies have led to a previously-unsuspected concept that tRNAs are not always ...