Tag Archives: TMM

In the past 5 years, RNA-Seq approaches, based on high-throughput sequencing technologies, are becoming an essential tool in transcriptomics studies. It is now commonly accepted that a normalization preprocessing step can significantly improve the quality of the analysis, in particular, ...

Recently, rapid improvements in technology and decrease in sequencing costs have made RNA-Seq a widely used technique to quantify gene expression levels. Various normalization approaches have been proposed, owing to the importance of normalization in the analysis of RNA-Seq data. ...

Next generation sequencing technologies are powerful new tools for investigating a wide range of biological and medical questions. Statistical and computational methods are key to analyzing massive and complex sequencing data. In order to derive gene expression measures and compare ...