Lara Stuart and her husband, David Lodge, first noticed the peculiar rash on their son Quincy’s face when he was just shy of 4 months old.Trips to the pediatrician and a dermatologist didn’t offer...
Read More »UCSF researchers recommend that all patients without Ras mutations undergo RNA sequencing to identify any fusions that might be treated with targeted therapies
Identifying Genetic Mutations May Unlock Cure for Challenging Malignancies UCSF Benioff Children’s Hospitals have successfully treated a months-old infant...
Read More »RNA-Seq reveals large differences in small RNA composition between human biofluids
Extracellular microRNAs (miRNAs) and other small RNAs are implicated in cellular communication and may be useful as disease biomarkers. UCSF researchers systematically compared small RNAs in 12 human biofluid types using RNA sequencing...
Read More »RNA-Seq reveals mRNA stability a marker in Alzheimer’s patients
Through mathematical modeling and collaboration with scientists at the University of California San Francisco (UCSF), McGill researchers, including Rached Alkallas, graduate student in the Department of Human Genetics and the primary author of the seminal study published in Nature Communications, ...
Read More »Featured RNA-Seq Job – Staff Research Associate I/II
The Staff Research Associate I/II (SRA I/II) will be working in a cell and molecular biology laboratory. The SRA I/II will be an integral member of a research team that is using CRISPR libraries in mammalian cell screens applied to ...
Read More »There is significant heterogeneity in the performance of RNA-Seq workflows to identify differentially expressed genes
RNA-Seq has supplanted microarrays as the preferred method of transcriptome-wide identification of differentially expressed genes. However, RNA-Seq analysis is still rapidly evolving, with a large number of tools available for each of the three major processing steps: read alignment, expression ...
Read More »Perturb-seq – Enables Large-Scale Analysis of Complex Genetic Interactions Using CRISPR-Based Gene Perturbation and Single-Cell RNA Sequencing
Researchers from UC San Francisco and the Broad Institute of MIT and Harvard have developed a new method for performing high-throughput functional screening of complex genetic interactions and resulting phenotypes in single cells, which they have dubbed “Perturb-seq.” The findings ...
Read More »Featured RNA-Seq Job – Sequence Pipeline Developer
University of California – San Francisco (San Francisco, CA) Req Number – 42709BR Job Title – Sequence Pipeline Developer Job Code and Payroll Title – 7275 PROGRAMMER/ANALYST III Location – Mission Bay Department Name – Psychiatry Work Days – Monday ...
Read More »Postdoc position available – Computational Biology
A Postdoc position is available in the Diaz laboratory, at UCSF. As part of our lab’s participation in an NIH BRAIN Initiative Award (http://www.braininitiative.nih.gov/nih-brain-awards.htm), and our role in the Brain Tumor Research Center (http://neurosurgery.ucsf.edu/index.php/research_BTRC.html), we will be single-cell sequencing over ...
Read More »UCSF/Fluidigm Paper Proves Shallow Sequencing of Related Single Cells Sufficient to Harvest Meaningful Biological Information
New Method Decreases the Cost of Single-Cell Sequencing; Frees Up Resources to Analyze More Cells SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–In a paper published in Nature Biotechnology this week, UC San Francisco and Fluidigm Corporation (NASDAQ:FLDM) scientists have demonstrated that shallow ...
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