Growing evidence suggests that human gene annotation remains incomplete; however, it is unclear how this affects different tissues and our understanding of different disorders. A team led by researchers at University College London detect...
Read More »SCENT – Single-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome
The ability to quantify differentiation potential of single cells is a task of critical importance. Here researchers from the University College London demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation potency of a single cell can be approximated by ...
Read More »LaSSO, a strategy for genome-wide mapping of intronic lariats and branch-points using RNA-Seq
Both canonical and alternative splicing of RNAs is governed by intronic sequence elements and produces transient lariat structures fastened by branch-points within introns. To map precisely the location of branch-points on a genomic scale, researchers at University College London developed ...
Read More »A comparison of RNA-seq and exon arrays for whole genome transcription profiling
The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing microarray technology. In this study a team led by scientists from the University College London directly compare exon microarrays to RNA-seq ...
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