Preparation of Sequencing RNA Libraries through Chemical Cross-linking Coupled to Affinity Purification (cCLAP)

October 24, 2018 Leave a comment 1,615 Views

Ribonucleoprotein particles (mRNPs) are complexes consisting of mRNAs and RNA-binding proteins (RBPs) which control mRNA transcription localization, turnover, and translation. Some mRNAs within the...

Profiling the nucleobase and structure selectivity of anticancer drugs and other DNA alkylating agents by RNA-Seq

May 10, 2018 Leave a comment 1,766 Views

Drugs that covalently modify DNA are components of most chemotherapy regimens, often serving as first-line treatments. Classically the chemical reactivity of DNA alkylators has been determined in vitro with...

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Preparation of Sequencing RNA Libraries through Chemical Cross-linking Coupled to Affinity Purification (cCLAP)

Profiling the nucleobase and structure selectivity of anticancer drugs and other DNA alkylating agents by RNA-Seq

scONE-seq – A single-cell multi-omics method enables simultaneous dissection of phenotype and genotype heterogeneity from frozen tumors

Phasik – inferring cell cycle phases from a partially temporal network of protein interactions

Single-cell transcriptomic profiling of Crohn’s disease reveals a detailed picture of inflammation in the gut

Gene expression model inference from snapshot RNA data using Bayesian non-parametrics

LeukemiaDB – a comprehensive human leukemia transcriptome database

Temporal transcriptomics analysis finds mating causes ‘jet lag’ in female fruit flies, changing behavior

DGAN – improved downstream functional analysis of single-cell RNA-sequence data