High-throughput single-cell gene expression experiments can be used to uncover branching dynamics in cell populations undergoing differentiation through pseudotime methods. Researchers from...
Read More »Bayesian estimation of differential transcript usage from RNA-seq data
Next generation sequencing allows the identification of genes consisting of differentially expressed transcripts, a term which usually refers to changes in the overall expression level. A specific type of differential expression is differential transcript usage (DTU) and targets changes in ...
Read More »Buliding a Human from Transcriptional Profiles
The manual for human development is written in the genetic code of our DNA. Our genes encode the instructions to make specific types of molecules that are needed to either build the human body or to control its day-to-day operations. ...
Read More »RNAcentral 1.0 provides a single access point to non-coding RNA data, vastly improving research into gene products
RNAcentral, the first unified resource for all types of non-coding RNA data, has been launched today by the RNAcentral Consortium. It aggregates information from a federation of expert databases, and provides tools for easy browsing. The initial release of RNAcentral ...
Read More »Revealing human-growth patterns in transcriptomic data
Making sense of childhood growth Background Dr Adam Stevens, is a human development systems biologist working in Professor Peter Clayton’s group at the UK’s University of Manchester. In addition to industrially-funded and commercially-sensitive research into drug responses, Dr. Stevens and ...
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