When the human genome was first sequenced, experts predicted they would find about 100,000 genes. The actual number has turned out to be closer to 20,000, just a few thousand more than fruit flies have. The question logically arose: how ...
Read More »First Atlas of Body Clock Gene Expression in Mammals Informs Timing of Drug Delivery and Emerging Field of Chronotherapy
Penn Medicine study has implications for 100 top-selling US drugs, half of which target daily-oscillating genes PHILADELPHIA — A new effort mapping 24-hr patterns of expression for thousands of genes in 12 different mouse organs – five years in the making ...
Read More »Library generation introduces significant biases in RNA-seq data, adding extreme variability to coverage and read-depth
RNA-seq is a powerful technique for identifying and quantifying transcription and splicing events, both known and novel. However, given its recent development and the proliferation of library construction methods, understanding the bias it introduces is incomplete but critical to realizing ...
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