Tag Archives: University of Würzburg

Transcriptomics, i.e., the quantification of cellular RNA transcripts, is a powerful way to gauge the physiological state of either bacterial or eukaryotic cells under a given condition. However, traditional...

Researchers at the University of Würzburg have constructed a powerful and modular pipeline called ANNOgesic that provides the required analyses and simplifies RNA-Seq-based bacterial and archaeal genome annotation. It is a modular, command-line tool that can integrate different types of RNA-Seq data ...

Infectious diseases are a leading cause of mortality worldwide. The development of novel therapies or vaccines requires improved understanding of how viruses, pathogenic fungi or bacteria cause illnesses. Some bacterial pathogens such as Salmonella invade and replicate within human cells. ...

Bacteria express many small RNAs for which the regulatory roles in pathogenesis have remained poorly understood due to a paucity of robust phenotypes in standard virulence assays. Here, researchers from the University of Würzburg used a generic ‘dual RNA-seq’ approach ...

The development of deep sequencing technology has greatly facilitated transcriptome analyses of both prokaryotes and eukaryotes. RNA-sequencing (RNA-seq), which is based on massively parallel sequencing of cDNAs, has been used to annotate transcript boundaries and revealed widespread antisense transcription as ...

This year’s recipients of the most important prize for early career researchers in Germany have been announced. The selection committee, appointed by the Deutsche Forschungsge-meinschaft (DFG, German Research Foundation) and the German Federal Ministry of Education and Research (BMBF), has ...

RNA-Seq has become a potent and widely used method to qualitatively and quantitatively study transcriptomes. In order to draw biological conclusions based on RNA-Seq data, several steps some of which are computationally intensive, have to be taken. Researchers at the ...

RNA-sequencing has revolutionized the quantitative and qualitative analysis of transcriptomes in both prokaryotes and eukaryotes. It provides a generic approach for gene expression profiling, annotation of transcript boundaries and operons, as well as identifying novel transcripts including small noncoding RNA ...